How accurately can we capture brain connections with MRI?
We are using Diffusion Tensor Imaging (DTI) and probabilistic tractography to predict the trajectory of visual brain pathways in primates. We compare these results to the actual neuronal connections in the same brain - revealed with small injections of tracers. Combining post mortem histology with non-invasive imaging methods, this research quantifies the extent to which MRI plus tractography can reveal real connectivity between specific brain areas.